EFFECT OF STEM BARK EXTRACT OF Kigelia africana ON LIVER AND KIDNEY FUNCTION OF ALLOXAN INDUCED DIABETIC RATS

Authors

Keywords:

Kigelia Africana, alloxan, GC-MS, kidney, liver function

Abstract

Kigelia africana or commonly known as the sausage tree is known to be useful in treating stomach problem, pneumonia, toothache, increases production of milk in the lactating woman, treating sores, skin ulcer etc. The aim of this study was to investigate the effect of methanolic stem bark extract of Kigelia africana (SBEka) on liver and kidney function of alloxan-induced diabetic rats. Gas chromatography-mass spectrometry (GC-MS) analysis was carried out on the plant extract which reveals the presence of 52 different chemical constituents that include n-hexadecanoic acid, nonanoic acid, tetradecanoic acid etc. These constituents are believed to various medicinal attributes such as antioxidant, hypocholesterolemic, nematicide, pesticide, antiandrogenic etc. This study shows that alloxan has less effect on the kidney function of albino rats due to the insignificant difference (P<0.05) in urea and creatinine levels between the diabetic control group and the normal control group and the plant extract have less side effect on kidney due to the significant decrease (P<0.05) found in all the kidney parameters except urea. The study also shows that alloxan has toxic effect to the liver function of albino rats due to the significant increase (P<0.05) in AST,ALT and ALP levels, however the plant extract shows hepatoprotective potential due to the significant decrease in those liver parameters. Hence, this study has revealed the effect of alloxan on liver and the plant extract significantly decreases the liver damage

Dimensions

Chaney, A.L. and Marbach, A.L. (1962). Clin. Chem; 8: 130

Etuk, E.U. and Muhammed, B.J. (2010). Evidence based of chemical method of induction of diabetes mellitus in experimental animals. Asian Journal of Experimental Biological Sciences, 1(2): 331-336

Fawcett, J.K. and Scott, J.E. (1960). J. Clin. Path. 13: 156

Forcados, G.E., Chinyere, C.N., and Shu, M.L. (2016). Kigelia africana: Therapeutic and Toxic Potential. J Med Surg Pathol 1: 122. doi:10.4172/2472-4971.1000122

Harris, D. C. (1995). Quantitative Chemical Analysis. W. H. Freeman and Company, New York. Chapter 21

Iwalokun, B.I., Alibi-Sofunde, J.A., Odunala, T., Magbagbeola, O.A and Akinwande, A.I. (2006). Hepatoprotective and anti-oxidant activities of Vernonia amygdalina on acetaminophen-induced hepatic damage in mice. J. Med. Food. 526-530.

Johnson, M., Longe, A. O., Campbell, C. A. and Omotayo, M. A. (2014). Evaluation Of Antidiabetic And The Effect Of Methanolic Leaf Extract Of Jatropha Curcas On Some Biochemical Parameters In Alloxaninduced Diabetic Male Albino Rats. European Journal of Medicinal Plants: 1501-1512.

Kang, J., Dai, X. S., Yu, T. B., Wen, B. and Yang, Z. W. (2005). Glycogen accumulation in renal tubules, a key morphological change in the diabetic rat kidney. Acta. Diabetol, 42: 110-116.

Kenkel, J. (2003). Analytical Chemistry for Technicians. CRC Press LLC. Boca Raton. Pp. 108-109.

Kirby, G.C. (1996). Medicinal plants and the control of protozoal disease, with particular reference to malaria. Trans R Soc Trop Med Hyg. 90:605–9.

Makoshi, M.S., Oladipo, O.O., Gotep, J.G., Forcados, G.E., & Shu ML, et al. (2016). Safety evaluation of Kigelia Africana in albino rats and BHK-21 cell line. Comparative Clinical Pathology 25 :1618-5641.

Navarro, C.M., Montilla, P.M., Martin, A., Jimenez, J. and Utrilla, P.M. (1993). Free radicals scavenger and antihepatotoxic activity of Rosmarinus. Plant Medicine. 312–314.

Nwanjo, H.U. (2007). Studies on the effect of aqueous extract of Phyllanthus niruri on plasma glucose level and some hepatospecific markers in diabetic Wistar rats. Int. J. Lab. Med. 2(2):1-18.

Oduola, T., Adeniyi, F.A., Ogunyemi, E.O., Idowu, T.O. and Subair, H.G. (2007). Toxicity studies on an unripe carica papaya aqueous extract; Biochemical and hematological effects in wistar albino rats. J. Med. Plants Res., 1: Pp. 1-4.

Omage, K., & Azeke, A.M. (2014). Medicinal Potential of Kigelia Africana Leaves. Advances in Research. 2(11):655–65

Onunogbo, C.C., Ohaeri, O.C. and Eleazu, C.O. (2012). Effect of mistletoe (Vascium album) extract on the blood glucose, liver enzyme and electrolyte balance in alloxan induced diabetic rats. Am. J. Biochem. Mol. Biol. Issn 2150-4210

Reitman, S. and Frankel, S. (1957). Amer. J. Clin Path; 28: P. 56.

Rukshana, M.S., Doss, A. and Kumari Pushpa Rani, T.P. [2017]. Phytochemical Screening and GC-MS Analysis of Leaf Extract of Pergulariadaemia (Forssk) Chiov. Asian Journal of Plant Science and Research, 7(1):9-15

Saroja, K., Elizabeth, J.D. and Gopalakrishnan, S. [2009]. Wound healing activity of the leaves of Dipteracantus patulus (Jacq.) Nees. Pharmacologyonline ; 2:462-9.

Sermakkani, M. And Thangapandian, V. [2012]. Gc-Ms Analysis Of Cassia Italica Leaf Methanol Extract . Asian Journal of Pharmaceutical and Clinical Research Vol 5, Issue 2. 90-94

Yadav, S.N.S and Bhattacharya, A.B. (2018). Effect of diabetes on renal function parameters in tertiary care hospital. International Archives of Integrated Medicine. 81-85.

Yakubu, O.E., Ojogbane, E., Nwodo, O.F.C., Nwaneri-Chidozie, V.O. and Dasofunjo, K. (2013). Effect of Vitexdoniana ethanol leaf extract on renal function in diabetic rats. European Journal of Experimental Biology, 3(3):630-634

Published

14-04-2020

How to Cite

EFFECT OF STEM BARK EXTRACT OF Kigelia africana ON LIVER AND KIDNEY FUNCTION OF ALLOXAN INDUCED DIABETIC RATS. (2020). FUDMA JOURNAL OF SCIENCES, 4(1), 490-497. http://www.fjsadmin.fudutsinma.edu.ng/index.php/fjs/article/view/71

Issue

Vol. 4 No. 1 (2020): FUDMA Journal of Sciences - Vol. 4 No. 1

Section

Research Articles
Copyright & Licensing

FUDMA Journal of Sciences

How to Cite

EFFECT OF STEM BARK EXTRACT OF Kigelia africana ON LIVER AND KIDNEY FUNCTION OF ALLOXAN INDUCED DIABETIC RATS. (2020). FUDMA JOURNAL OF SCIENCES, 4(1), 490-497. http://www.fjsadmin.fudutsinma.edu.ng/index.php/fjs/article/view/71