ACUTE AND SUBCHRONIC TOXICITY STUDIES OF THE CARBONATED DRINK EXTRACT OF ENANTIA CHLORANTHA STEM BARK

Authors

  • Gabriel Akinwale Sotade
    Molecular Biology Department, Federal College of Veterinary and Medical Laboratory
  • Eusebius Chukwu Onyeneke
    University of Benin image/svg+xml
  • Samuel Ifidon Ojeaburu
    University of Benin image/svg+xml
  • Patricia Chioma Ofoha
    David Umahi Federal University of Health Sciences, Uburu
  • Waheed Muibi
    Kwara State College of Health Technology Offa
  • Joseph Eniola Sotade
    Kings University, Gbongan-Osogbo Road, Odeomu
  • Oluwamuyiwa Olanrewaju Godson
    Federal College of Veterinary & Medical Laboratory Technology, Vom
  • Olumuyiwa Mark Adu
    Federal College of Veterinary & Medical Laboratory Technology, Vom
  • Nathaniel Olajire Olawuyi
    Federal College of Veterinary & Medical Laboratory Technology, Vom
  • Josephat Ejike Ozor
    Federal College of Veterinary & Medical Laboratory Technology, Vom
  • Abdulrahman Shehu
    Federal College of Veterinary and Medical Laboratory Technology, Vom

Keywords:

Toxicity, Carbonated drink, Enantia chlorantha, Liver, Kidney

Abstract

Enantia chlorantha is a plant known for its medicinal properties, particularly in traditional medicine across West Africa. The acute and sub chronic toxicity studies of the extract were evaluated. Group 1 animals were given distilled water while Groups 2 – 4 were administered 50, 150 and 250 mg/kg body weight of the extract respectively. The LD50 values from the acute toxicity study of the extracts were greater than 5000 mg/kg body weight. The RBC, Hb, HCT, MCV, MCH, MCHC, and platelets levels were higher (p > 0.05) in all the extract treated groups. There was no significant difference (p > 0.05) in the serum TC, TG, HDL, LDL, VLDL - cholesterol levels in all the treated groups when compared to the control group. This showed that the extracts did not affect the lipid profile of the mice. There were no significant (p > 0.05) difference in ALP, AST, ALT and GGT activities. The Potassium levels were non-significantly (p > 0.05) higher in the extracts treated groups when compared to the control group. Significant (p < 0.05) increased in GSH concentration was observed in the mice administered 250 mg/kg body weight of the extract when compared with the control group. No prominent hepatocellular or glomerular damages were observed in the vital organs. The findings suggest that the carbonated drink extract of E. chlorantha stem bark is safe for use and therefore supports the traditional use of the plant in treating various disease condition.

Dimensions

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Published

30-06-2025

How to Cite

ACUTE AND SUBCHRONIC TOXICITY STUDIES OF THE CARBONATED DRINK EXTRACT OF ENANTIA CHLORANTHA STEM BARK. (2025). FUDMA JOURNAL OF SCIENCES, 9(6), 141-147. https://doi.org/10.33003/fjs-2025-0906-3533

Issue

Vol. 9 No. 6 (2025): FUDMA Journal of Sciences - Vol. 9 No. 6

Section

Research Articles
Copyright & Licensing

FUDMA Journal of Sciences

How to Cite

ACUTE AND SUBCHRONIC TOXICITY STUDIES OF THE CARBONATED DRINK EXTRACT OF ENANTIA CHLORANTHA STEM BARK. (2025). FUDMA JOURNAL OF SCIENCES, 9(6), 141-147. https://doi.org/10.33003/fjs-2025-0906-3533

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